| 1 | 1.1 | Relevant properties of NPs to engage with endogenous processes defined | UNIMA |
| 1 | 1.2 | Validation of use of endogenous processes by model carrier particles | SDU |
| 1 | 1.3 | Outline of expected degradation and clearance outcomes of NP carriers. | UNIMA |
| 1 | 1.4 | Synthesis and characterization of chemical purity of carriers, as well as embedded materials. | UNIMA |
| 1 | 1.5 | In depth physiochemical characterization of all carriers in situ prior to and during uptake and final sub-cellular localisation / following transcytosis. | NUID UCD |
| 1 | 1.6 | Redesigned nano-carriers according to a basic parameter set (size, shape, surface, bionanointerface). | SDU |
| 2 | 2.1 | Characterization of cellular functions (cell lines, primaries, endothelia and epithelia restored functions –transcytosis etc.). | HZI |
| 2 | 2.2 | Reconstruction of relevant barrier components and assessment of nanocarrier interactions | HZI |
| 2 | 2.3 | Standardised biological fluid environment to ensure representative ‘protein corona’ around particles. | NUID UCD |
| 2 | 2.4 | Time-resolved intra-barrier nanoparticle distributions in presence of stress or other environmental conditions. | ACS |
| 2 | 2.5 | Analytical tools for tracking & extraction of NPs along uptake/translocation pathways. | MPG |
| 3 | 3.1 | Cross-platform protocols in vivo dosing | KCL |
| 3 | 3.2 | Protocols for primary cells and tissue extraction | UNIVBRIS |
| 3 | 3.3 | Classification and analysis of relevant (species dependent) mucous | KCL |
| 4 | 4.1 | Creation of data-basing tools | NUID UCD |
| 4 | 4.2 | Database of characterized endogenous pathways in cells and biological barriers | MPG |
| 4 | 4.3 | Computational modelling of barrier crossing | EPOS |
| 5 | 5.1-5.6 | Periodical scientific and collaboration (secondments) progress reports | NUID UCD, All |
| 5 | 5.7-5.15 | Periodical reports of fellows’ seminar and congress presentations / participation | NUID UCD, All |
| 5 | 5.16 | Fellows’ PhD thesis | All |
| 5 | 5.17 | Report of fellows selection and appointment | NUID UCD, All |
| 5 | 5.18-5.32 | Periodical reports of fellows’ proficiency, rotations, participation in journal clubs | NUID UCD, All |
| 5 | 5.33 | Report of fellows completion of graduate courses | NUID UCD, All |
| 5 | 5.34-5.36 | Periodical reports of fellows participation to training courses and activities | NUID UCD, All |
| 5 | 5.37-5.38 | Mid-term and final reports of PathChooser research & training outcomes | NUID UCD, All |
| 6 | 6.1 | Development of a website | All |
| 6 | 6.2 | Report on the Mechanisms of nanoparticle passage across biological barriers. All fellows will disseminate their results at this conference | KCL, All |
| 6 | 6.3 | Report on Meet-the-Manager Workshop. All fellows are required to take part | All |
| 6 | 6.4 | Report on the Therapeutic strategies involving nanoparticles actively transporting across biological barriers International conference on. All fellows will disseminate their results at this conference | EPOS, All |
