Delivering therapeutic cargos to target sites for medical applications is hampered by multiple levels of barriers. For successful delivery, the therapeutic cargo has to cross, for example, a blood vessel, placenta or mucus layer in the lungs depending on the target, deeply penetrate the tissue by transcytosis, efficiently internalize into target cells by endocytosis and escape from the endo-lysosomal compartments to the cytosol if the therapeutic cargo’s action is in the cytosol.
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The EU INFRASTRUCTURE project QualityNano comes near completion and will hold its final conference on 15th to 17th July 2015 in Heraklion, Crete, Greece. Local host for the meeting is the Foundation for Research & Technology – Hellas (FORTH). This conference is jointly organized with the EU NMP project NANoREG which is already in its second year and addresses the crucial question of regulatory research in the nanosafety area.
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Positions are advertised on the EURAXESS website and further information is available at the following links:
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As a result of the rapid expansion in the use of nanoparticles (NPs) in recent years, it is imperative that we advance our understanding of NP interactions with biological systems in order to establish safety standards and improve the design of nanomaterials. Such mechanisms can of course be investigated in in vivo systems,
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Lysosomal storage disorders (LSDs) are a group of ~50 genetic diseases of lysosomal function resulting in an intra-lysosomal accumulation of undegraded material with a combined incidence of 1:5.000 live births (Fuller et al. 2006). The clinical phenotype of LSDs varies widely from skeletal and visceral manifestation to severe CNS involvement depending on the defective protein and storage material involved.
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The lungs are the vital organs in charge of delivering oxygen to the cells. At the same time they also protect the organism from many threats contained in the air such as pollutants and pathogens. The mechanism by which these functions are achieved is extraordinarily complex to be explained in short,
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Humans have always been curious and it has been curiosity to push our species’ evolution. Man wants to discover the realty and to use his knowledge to manipulate the world, not only in order to adapt the environment to him but even to adapt him to the environment, as in the case of medicine.
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March is not only the first month of spring, but also the month when some really important scientific discoveries happened: Antoine Henri Becquerel discovered radioactivity, which led to his and Pierre and Marie Curie’s Nobel Prize in Physics in 1903; Dmitri Ivanovich Mendeleev presented his periodic table to the Russian Chemical Society;
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On the 10th-11th of February 2014, the Centre for BioNano Interactions (CBNI), University College Dublin, welcomed a European audience to a two-day launch meeting of the €3 million, EU FP7-funded, Marie Curie Initial Training Networks (ITN) Project, PathChooser. In attendance were the Fellows who have already been appointed and the Principle Investigators who will guide them on their chosen,
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