Biological barriers impede the application of bio-macromolecule based drugs in the clinics [1]. Small interfering RNA (siRNA) based drugs can be delivered to cells via endocytosis to silence the expression of disease causing genes [1, 2]. A major bottleneck in delivery, however, is the escape of siRNAs from endosomes to cytosol,

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Mucus is very difficult to clean off and it is usually a tough job trying to maintain hygiene when suffering from a flu. This should not make you fret, as its stickiness is a key in-built feature that mediates its functions. Bacteria, viruses, and dust find it equally as hard as us to escape from mucus.

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